The Role of Recombinant Interleukin 11 in Megakaryocytopoiesis
نویسندگان
چکیده
منابع مشابه
Recombinant human interleukin-11 directly promotes megakaryocytopoiesis in vitro.
We have investigated the mechanism of action of the thrombopoietic cytokine, recombinant human interleukin-11 (rhIL-11), on megakaryocytopoiesis in vitro. We have shown that rhIL-11-induced murine and human megakaryocytopoiesis are not mediated by thrombopoietin (Tpo). Murine megakaryocytes (MKs) were produced from bone marrow (BM) mononuclear cells cultured with rhIL-11, IL-3, and a combinatio...
متن کاملInterleukin-11 enhances human megakaryocytopoiesis in vitro.
We investigated the effect of recombinant human interleukin-11 (rhIL-11) on human megakaryocytopoiesis. Nonadherent and T-cell-depleted human bone marrow (BM) mononuclear cells were cultured in a serum-free agar culture system. rhIL-11 alone did not stimulate the growth of human megakaryocyte colonies. However, when rhIL-11 was combined with optimal or suboptimal doses of rhIL-3, the number and...
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15 صفحه اولRecombinant human interleukin-11 stimulates megakaryocytopoiesis and increases peripheral platelets in normal and splenectomized mice.
The effects of recombinant human interleukin-11 (rhIL-11) on in vivo mouse megakaryocytopoeisis were examined. Normal C57Bl/6 mice and splenectomized C57Bl/6 mice were treated for 7 days with 150 micrograms/kg rhIL-11 administered subcutaneously. In normal mice, peripheral platelet counts were elevated compared with vehicle-treated controls after 3 days of rhIL-11 treatment and remained elevate...
متن کاملthe role of thematic structure in comprehending spoken language
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ژورنال
عنوان ژورنال: Stem Cells
سال: 1996
ISSN: 1066-5099,1549-4918
DOI: 10.1002/stem.5530140707